Journal article
Neuregulin-1 and schizophrenia in the genome-wide association study era
MS Mostaid, D Lloyd, B Liberg, S Sundram, A Pereira, C Pantelis, T Karl, CS Weickert, IP Everall, CA Bousman
Neuroscience and Biobehavioral Reviews | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2016
Abstract
Clinical and pre-clinical evidence has implicated neuregulin 1 (NRG1) as a critical component in the pathophysiology of schizophrenia. However, the arrival of the genome-wide association study (GWAS) era has yielded results that challenge the relevance of NRG1 in schizophrenia due to the absence of a genome-wide significant NRG1 variant associated with schizophrenia. To assess NRG1's relevance to schizophrenia in the GWAS era, we provide a targeted review of recent preclinical evidence on NRG1's role in regulating several aspects of excitatory/inhibitory neurotransmission and in turn schizophrenia risk. We also present a systematic review of the last decade of clinical research examining NRG..
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Grants
Awarded by Brain and Behavior Research Foundation
Funding Acknowledgements
MM was supported by a Cooperative Research Centre for Mental Health Top-up Scholarship. SS and AP were supported by One-in-Five Association Incorporated. CP was supported by an NHMRC Senior Principal Research Fellowship (#628386), and a Brain and Behavior Research Foundation (NARSAD) Distinguished Investigator Award. TIC is supported by a Career Development Fellowship (Level 2: #1045643) and a project grant (#1102012) from the National Health and Medical Research Council (NHMRC), as well as the Rebecca L. Cooper Medical Research Foundation Ltd. CSW is supported by Schizophrenia Research Institute (utilizing infrastructure funding from the NSW Ministry of Health and the Macquarie Group Foundation), the University of New South Wales, and Neuroscience Research Australia. CSW is a recipient of a National Health and Medical Research Council (Australia) Senior Research Fellowship (#1021970). CAB was supported by a University of Melbourne Ronald Phillip Griffith Fellowship and Brain and Behavior Research Foundation (NARSAD) Young Investigator Award (#20526). None of the Funding Sources played any role in interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.